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ATCC human microglia cells
Human Microglia Cells, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cd11b microbeads  (Miltenyi Biotec)
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Cd11b Microbeads, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human microglia clone 3 (hmc3) cells  (Procell Inc)
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Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and <t>HMC3</t> (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.
Human Microglia Clone 3 (Hmc3) Cells, supplied by Procell Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti cd11b microbeads  (Miltenyi Biotec)
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Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and <t>HMC3</t> (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.
Anti Cd11b Microbeads, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human microglia primary cell culture complete media with serum  (Celprogen Inc)
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Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and <t>HMC3</t> (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.
Human Microglia Primary Cell Culture Complete Media With Serum, supplied by Celprogen Inc, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human microglia cells  (Celprogen Inc)
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Celprogen Inc human microglia cells
Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and <t>HMC3</t> (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.
Human Microglia Cells, supplied by Celprogen Inc, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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murine sim a9 microglia  (ATCC)
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Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and <t>HMC3</t> (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.
Murine Sim A9 Microglia, supplied by ATCC, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and HMC3 (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.

Journal: Neural Regeneration Research

Article Title: Mesenchymal stem cell–derived small extracellular vesicles enhance the therapeutic effect of retinal progenitor cells in retinal degenerative disease rats

doi: 10.4103/NRR.NRR-D-23-02108

Figure Lengend Snippet: Microglial suppression of RCS rats mediated by co-transplantation of RPCs with M-sEVs. (A) Representative confocal images of Iba1 staining in the RPCs and RPCs + M-sEVs groups at 2 and 4 weeks post transplantation. Enlarged orthogonal view of M-sEVs at the injected area (right panel) shows co-localization of the M-sEVs with microglia in the subretinal space. (B) Statistical analysis of the number of Iba1-positive cells in each group in A. (C, D) Representative confocal images showing the localization of MSC-sEVs (PKH26 staining) with F-actin-labeled BV2 (C) and HMC3 (D) microglial cells stimulated with LPS. Scale bars: 20 μm (A), 10 μm (A, enlarged orthogonal view), 50 μm (C, D). (E) RT-PCR analysis showing relative mRNA expression levels of IL-1β, IL-6, and TNF-α in the mouse (BV2) and human (HMC3) microglial cell lines. Data are expressed as means ± SD ( n ≥ 3 for Iba1 staining; n = 3 for real-time PCR); * P < 0.05, ** P < 0.01, *** P < 0.001 (B: Welch’s t -test; D: Welch’s one-way analysis of variance followed by Dunnett’s T3 multiple-comparison test). DAPI: 4′,6-Diamidino-2-phenylindole; EGFP: enhanced green fluorescent protein; Iba1: ionized calcium-binding adapter molecule 1; IL-1β; interleukin 1 beta; IL-6: interleukin 6; LPS: lipopolysaccharide; M-sEVs: mesenchymal stem cell–small extracellular vesicles; RT-PCR: real-time polymerase chain reaction; RPCs: retinal progenitor cells; RCS: Royal College of Surgeons; TNF-α: tumor necrosis factor α; w: weeks.

Article Snippet: Human microglia clone 3 (HMC3) cells were purchased from Procell Life Science & Technology Co., Ltd. (Wuhan, China, Cat# CL-0620, RRID: CVCL_II76) and were cultured in alpha minimum essential medium (Cat# SH30265.01, Hyclone) containing 10% FBS.

Techniques: Transplantation Assay, Staining, Injection, Labeling, Reverse Transcription Polymerase Chain Reaction, Expressing, Real-time Polymerase Chain Reaction, Comparison, Binding Assay